Lorraine Bracco as Marge Simpson
Jacob Kogan as Bart Simpson
AnnaSophia Robb as Lisa Simpson
Jeff Goldblum as Moe
William H. Macy as Ned Flanders
Ian McDiarmid as Mr. Burns
Allison Janney as Edna Krabappel
David Schwimmer as Rev. Lovejoy
Steve Buscemi as Dr. Nick
James Earl Jones as Dr. Hibbert
Orlando Jones as Carl
Tom Arnold as Chief Wiggum
Kevin Smith as Comic Book Guy
Benicio del Toro as Snake Jailbird
Justin Long as Squeaky Voiced Teen